Comment on: Use of parenteral methotrexate significantly reduces the need for biological therapy

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Use of parenteral methotrexate significantly reduces the need for biological therapy.

SIR, We read with interest Bharadwaj et al.’s letter [1] demonstrating encouraging responses to parenteral MTX in a retrospective analysis of 32 patients with RA. We conducted a prospective study to investigate the effectiveness of parenteral MTX in a cohort of patients with RA [2] for whom oral MTX was ineffective or not tolerated. In addition, we assessed whether the change from oral to paren...

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Determination of Methotrexate in Biological Fluids and a Parenteral Injection Using Terbium-Sensitized Method

A new sensitive, simple and rapid method for determination of methotrexate (MTX) was developed based on quenching effects of MTX on the fluorescence intensity of Tb3+-1,10-phenanthroline complex. The fluorescence intensity was measured with excitation wavelength of 300 nm and emission wavelength of 545 nm and the quenched fluorescence intensity is proportional to the concentration of MTX in Tris...

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Determination of Methotrexate in Biological Fluids and a Parenteral Injection Using Terbium-Sensitized Method

A new sensitive, simple and rapid method for determination of methotrexate (MTX) was developed based on quenching effects of MTX on the fluorescence intensity of Tb3+-1,10-phenanthroline complex. The fluorescence intensity was measured with excitation wavelength of 300 nm and emission wavelength of 545 nm and the quenched fluorescence intensity is proportional to the concentration of MTX in Tris...

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ژورنال

عنوان ژورنال: Rheumatology

سال: 2008

ISSN: 1462-0324,1462-0332

DOI: 10.1093/rheumatology/ken250